Spy agent green kit cost
The mechanism of interaction is unclear those proposed in the medical literature include increased indocyanine green uptake by the liver cell, enhanced binding by specific hepatic carrier proteins, or more rapid excretion into bile. The half-life of indocyanine green was lower in patients taking the drugs concomitantly compared to patients with normal and abnormal liver function taking no concomitant medications. Phenobarbital: (Moderate) Phenobarbital may increase the clearance indocyanine green. Nitrofurantoin: (Moderate) Nitrofurantoin may increase the clearance of indocyanine green. Nifedipine: (Moderate) In a study of 9 healthy adults given 0.5 mg/kg of indocyanine green, nifedipine increased indocyanine green clearance by 14%. Collection of blood samples for analysis should be performed with anticoagulants that do not contain sodium bisulfite. Heparin: (Moderate) Heparin products that contain sodium bisulfite may reduce the absorption peak of indocyanine green. Haloperidol: (Moderate) Haloperidol may increase the clearance of indocyanine green. įor lymphatic mapping, administer as 4 interstitial injections into the cervix at the 3 and 9 o'clock positions with a superficial (1 to 3 mm) and a deep (1 to 2 cm) injection at each position.īelladonna Alkaloids Ergotamine Phenobarbital: (Moderate) Phenobarbital may increase the clearance indocyanine green. Inject a 5 mL IV bolus of 0.9% Sodium Chloride Injection immediately after the indocyanine green. Use isotonic saline to flush the residual dye from the cardiac catheter to avoid hemolysis.įor ophthalmic angiography studies, administer into the antecubital vein. Rinse the syringe that will be used for the injection with the Sterile Water for Injection provided. Adjust the amount and type of flush to avoid volume and/or sodium overload in pediatric patients.įor cardiac output studies, administer via the cardiac catheter. Immediately after indocyanine green injection, switch the access on the stopcock and flush the line with 10 mL of 0.9% Sodium Chloride Injection. The normal percentage disappearance rate in healthy subjects is 18% to 24% per minute.įor visualization of vessels, blood flow, and tissue perfusion, administer via a central or peripheral venous line using a 3-way stopcock attached to an injection port on the infusion line. Changing concentrations of indocyanine green can be monitored by ear densitometry or by obtaining blood specimens at timed intervals (i.e., photometric method). Study the patient in a fasting, basal state. Indocyanine green is administered as a rapid IV bolus.įor hepatic function studies, administer into the lumen of an arm vein as rapidly as possible, without allowing the dye to escape outside the vein. The dye is stable in whole blood and plasma, so samples obtained during testing may be read hours later. Storage: Indocyanine green is unstable in aqueous solution and must be used within 6 hours. The amount of Sterile Water for Injection to be used is determined by the procedure to be performed.įor hepatic function studies, dilute 25 mg indocyanine green with 5 mL of Sterile Water for Injection (5 mg/mL).įor visualization of vessels, blood flow, tissue perfusion, and extrahepatic biliary ducts, dilute 25 mg indocyanine green with 10 mL of Sterile Water for Injection (2.5 mg/mL).įor ophthalmic angiograms, dilute up to 40 mg indocyanine green with 2 mL of Sterile Water for Injection (up to 20 mg/mL).įor lymphatic mapping, dilute 25 mg indocyanine green with 20 mL of Sterile Water for Injection (1.25 mg/mL).ĭiscard the solution if the product precipitates. Under sterile conditions, dissolve the indocyanine green powder with Sterile Water for Injection.